Benefits of

Vitamin D3

Supports Bone Health*

Supports
Bone Health*

Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone. A longstanding Vitamin D deficiency has been associated with growth retardation and rickets in children, and osteoporosis or, in the most severe cases, osteomalacia in adults. Numerous studies demonstrate that combination of calcium and Vitamin D3 supplementation may help reduce risk of fractures.

Contributes to Normal Function of Immune System

Vitamin D3 is shown to help modulate the immune response. The Vitamin D receptors (VDR) are expressed by many cells of the immune system, such as the T cells, dendritic cells, and macrophages. Under specific circumstances, these cells can express the 1α-hydroxylase enzyme and produce l,25(OH)2D3, which acts locally to regulate the immune response by modulating innate and adaptive immunity & may help in reducing the risk of respiratory infections.

Contributes to Promote Teeth Mineralization

It is well established that adequate status for Vitamin D is required for efficient calcium absorption and for the maintenance of normal blood concentrations of calcium and phosphate that are in turn needed for the normal mineralization of teeth. Adequate intake of Vitamin D is needed to achieve a Vitamin D status that is sufficient for normal teeth mineralization throughout childhood and adolescence.

Contributes to Normal Cell Division

In many tissues, Vitamin D has important functions in regulation of cell proliferation and differentiation. It alters the growth and differentiation of numerous normal and pathological cell types by several mechanisms. Vitamin D slows cell cycle progression, affecting many regulators of this process.

Maintenance of Normal Muscle Function

Muscle weakness is a feature of the clinical syndrome of Vitamin D deficiency. Clinical symptoms of Vitamin D deficiency myopathy include proximal muscle weakness, diffuse muscle pain, and gait impairments such as waddling way of walking. The Vitamin D receptor is expressed in human muscle tissue, and its activation may promote de novo protein synthesis in muscle.

Reduces Fall Risk from Weak Muscles and Postural Instability

A reduction in the risk of falling among men and women 60 years of age and older is beneficial to human health by reducing the risk of bone fractures. Vitamin D along with calcium is known to reduce the risk of falling in elderly.

*FSSAI Approved claim for Vitamin D; 1: EFSA- maintenance of normal bones 2-6: In accordance with the European Food Safety Authority (EFSA), and approved health benefits of Vitamin D) (EFSA Journal 2009; 7(9):1227; (Drugs. 2023 May 6;83(8):665–685; A Critical Evaluation of Vitamin D – Basic Overview; 2016; J Investig Med. 2011 Aug;59(6):881–886.

Other Notable Benefits of

Vitamin D3

Supports Heart Health

Supports
Heart Health

Vitamin D deficiency has been associated with inflammation and endothelial and platelet dysfunction, which favors the risk of cardiovascular complications. Patients with hypertension and Vitamin D deficiency have a two-fold increased risk of cardiovascular complications and up to 52% more risk of stroke. Vitamin D might reduce the incidence of major cardiovascular events.
(Am Heart J. 2014; 167:283–91 Circulation. 2008; 4:503–511; Stroke. 2012; 43:1470–7; BMJ 2023; 381)

Helps Blood Sugar Regulation

Vitamin D also has receptors in pancreatic cells and exerts a regulatory action on glucose metabolism. The endocrine society suggest for adults with high-risk prediabetes, in addition to lifestyle modification, empiric Vitamin D supplementation to reduce the risk of progression to diabetes.

(A Critical Evaluation of Vitamin D – Basic Overview; 2016; The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 8, August 2024, Pages 1907–1947)

Supports Mood and Mental Health

Vitamin D3 is associated with improved mood and may help reduce the risk of depression and anxiety. Low levels of Vitamin D are linked to a higher incidence of mood disorders.

(Głabska D, Kołota A, Lachowicz K, Skolmowska
D, Stachoń M, Guzek D. The influence of vitamin D intake and status on mental health in children: a systematic review. Nutrients. 2021;13(3):952.)

Supports Healthy Pregnancy Outcomes

Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes e.g. hypertensive disorders of pregnancy, gestational diabetes mellitus (GDM), preterm birth, and low birthweight. Vitamin D during pregnancy may improve maternal and infant 25(OH)D concentrations and may play a role in maternal insulin resistance and fetal growth.

(J Acad Nutr Diet. 2020 May;120(5):898-924.e4; Nutr Diabetes. 2024 May 30;14(1):35)

Supports Fertility

Vitamin D levels regulate multiple enzymes involved in the production of steroid hormones, such as adrenal steroid hormones, sex hormones, and sex hormone signaling. Vitamin D metabolizes enzymes in the human testis and ejaculatory tract and is also associated with spermatozoa maturity. Vitamin D influences estrogen and progesterone levels that impact menstrual regularity, menopause, fertility, and pregnancy.
(Horm Metab Res. 2011 Mar;43(3):223-5; Ann Med Surg (Lond). 2023 Jun 5;85(7):3506–3511; Diagnostics 2023, 13(19), 3024)

Disclaimer: The information presented above is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.